Generic:

Hydrocortisone Sodium Succinate

Brand:

Eurocortef

Dosage Form and Strength:

100 mg

Availability:

Dry powder for injection in 6 mL vial

Each vial contains:

100 mg eq. of hydrocortisone (hydrocortisone sodium succinate)

Dosage and Administration:

The usual dose is the equivalent of 100 to 500 mg of hydrocortisone, repeated 3 or 4 times in 24 hours, according to the severity of the condition and the patient’s response. Children up to 1 year of age may be given 25mg, 1 to 5 years 50 mg, and 6 to 12 years 100 mg. In the treatment of severe shock the equivalent of up to 50 mg per kg body-weight in 24 hours has been given by slow intravenous injection over several minutes in divided doses, or by intravenous infusion. Fluids and
Electrolytes should be given as necessary to correct any associated metabolic disorder. Similar
doses to those specified above may also be given intramuscularly but the response is likely to be
less rapid than that observed following intravenous administration. Hydrocortisone Sodium
Succinate may be given by intravenous injection in a dose equivalent to 100mg to 300mg of Hydrocortisone.
In patients with adrenal insufficiency states supplementary corticosteroid therapy may be necessary
during some surgical operations and Hydrocortisone Sodium Succinate may be given intramuscularly or intravenously before surgery.
The equivalent of Hydrocortisone 100 mg may be given with premedication and repeated every 8
hours. For local administration by injection into soft tissues, Hydrocortisone Sodium Succinate is
usually given in a dose of 100mg to 200mg or as prescribed by the physician.

Indication:

Used in the management of all conditions in which corticosteroids are indicated. Also for
replacement therapy in acute or chronic adrenocortical insufficiency.

Contraindications:

During long course of corticosteroid therapy patients should be examined regularly, and in
particular, checked for hypertension, glycosuria, hypokalaemia, gastric discomfort and mental
changes. Measures to compensate for the adrenal inability to respond to stress include increasing
the dose to cover intercurrent illness or trauma such as surgery (with intramuscular administration
to cover vomiting.) Rapid intravenous injection of massive doses of corticosteroids may sometimes cause cardiovascular collapse and injections should therefore, be given slowly or by infusion. High dose should not be used for prolonged treatment.

Concurrent administration of barbiturates, Carbamazepine, phenytoin, primidone, or Rifampicin may enhance the metabolism and reduce the effects of corticosteroids.
Concurrent administration of corticosteroids with potassium depleting diuretics such as thiazides
or frusemides, may cause excessive potassium loss. There may be an increase incidence of
gastrointestinal bleeding and ulceration when corticosteroids are given with non-steroidal antiinflammatory
drugs. Response to anticoagulants may be altered by corticosteroids and
requirements of diabetic agents and antihypertensive may be increased.

Storage Condition:

Store at temperature not exceeding 30°C.

Distributed by:

SONCHEL PHARMA DISTRIBUTORS

9006 National Road, Camias
San Miguel, Bulacan

Imported  by:

EURO-CARE PRODUCTS, PHILS.

Tinio St., San Nicolas
Gapan City, Nueva Ecija

Manufactured by:

VYSALI PHARMACEUTICALS, LTD.

Cochin, India